IGF-1 Profile

Predictable mean IGF-1 levels at ~4.5 days1

  • IGF-1 levels were in the normal range throughout the week1
  • At steady state, IGF-1 levels peak approximately 2 days postdose, with the average weekly IGF-1 coinciding with approximately 4.5 days postdose1
  • Somatropin released from SKYTROFA® produces a dose-linear IGF-1 response1
    • Average change of 0.02 mg/kg resulting in a change in IGF-1 SDS of 0.171
Father taking picture of daughter while she rides a bike.

Mean (± SE) IGF-1 at steady state in pediatric GHD patients receiving a fixed dose of SKYTROFA 0.24 mg/kg/week (N = 11)2,3

Time (hour), Week 13

Thornton PS, Maniatis AK, Aghajanova E, et al. Weekly lonapegsomatropin in treatment-naïve children with growth hormone deficiency: the phase 3 heiGHt trial. J Clin Endocrinol Metab. 2021;106(11):3184-3195. doi:10.1210/clinem/dgab529. Reproduced by permission of Oxford University Press on behalf of the Endocrine Society.

Green zone represents IGF- 1 SDS normal range.

Once-weekly SKYTROFA makes dosing easy for patients and their healthcare professionals